Authors: Rupert RA Bourne, Tasneem Khatib
Categories: Optic Nerve Head
Source: Community Eye Health
Authors: Rupert RA Bourne, Tasneem Khatib
The key to detection and management of glaucoma is understanding how to examine the optic nerve head.
All types of glaucoma involve glaucomatous optic neuropathy. The key to detection and management of glaucoma is understanding how to examine the optic nerve head (ONH).
This article addresses the following
The ONH can be examined using a direct ophthalmoscope, an indirect ophthalmoscope, or a posterior pole lens with a slit lamp (Figure 1).
Many types of health professional can assess the ONH accurately after having appropriate training. Dilating the pupil makes this easier and will improve the accuracy of the examination, regardless of which instrument is used. Where the equipment is available, more sophisticated techniques such as ocular coherence tomography can also be used to complement the clinical examination of the ONH and provide quantitative measurements.
The time available to view the ONH is often short as the examination is uncomfortable for the patient. It is therefore essential that the examiner has a strategy for making the observations needed to distinguish a glaucomatous ONH from a normal ONH.
Before you start, you should first be able to recognise the characteristics of both a normal and a glaucomatous ONH, and be able to look for additional signs that could indicate a glaucomatous ONH.
Characteristics of the normal ONH (Figure 2)
The ONH, or optic disc, is a round/oval ‘plughole’ down which more than a million retinal nerve fibres descend through a sieve-like sheet known as the lamina cribrosa. The retinal nerve fibres are then bundled together behind the eye to form the optic nerve which then continues towards the brain.
The retinal nerve fibres are spread unevenly across the surface of the retina in a thin layer which has a ‘feathery’ appearance, best seen immediately above and below the disc (Figure 3).
As the nerve fibres approach the edge of the disc they pour over the scleral ring (which marks the edge of the disc) and then down its inner surface. The dense packing of nerve fibres just inside the scleral ring is visualised as the neuroretinal rim. The cup is the area central to the neuroretinal rim. The cup edge (where it meets the neuroretinal rim) is best seen by the bend in small and medium-sized blood vessels as they leave, or descend into, the cup.
Most normal discs are more vertically oval and their cup more horizontally oval.
In addition, most (but not all) normal ONHs obey the ‘ISNT’ the Inferior (lower) rim is usually thicker than the Superior (upper) rim, which is thicker than the Nasal rim (inner, nearest the nose). The Temporal rim (outer, nearest the temple) is the thinnest.
Characteristics of a glaucomatous ONH
Additional signs which should heighten suspicion of a glaucomatous ONH
Strategy: distinguishing a glaucomatous ONH from a normal ONH
Is the glaucomatous optic neuropathy worsening or progressing?
The appearance of any of the features of a glaucomatous ONH, or the exacerbation of these features compared to a previous record, is indicative of a progression/worsening of the disease.
Disc haemorrhages may be present for two weeks to three months and are an important prognostic sign of progression. An accurate record requires careful observation and a detailed drawing, and photographic documentation (preferably stereophotography) is highly recommended.
Other imaging devices (see below) assist the clinician in detection of glaucoma when it is unclear from clinical examination whether the optic discs are glaucomatous.
These devices also offer progression analyses to look for structural deterioration, but these are not a surrogate for a detailed clinical examination.
Progressive worsening of the visual fields should correlate with structural changes at the ONH.
Structural imaging of the optic nerve in glaucoma
As part of the clinical assessment of the optic nerve in glaucoma, the International Council of Ophthalmology (ICO) in their Guidelines for Glaucoma Care suggest that structural imaging of the optic nerve may provide a useful but not essential adjunct to direct ophthalmoscopy, slit lamp biomicroscopy and fundus photography when evaluating the optic nerve.
A variety of technologies to analyse the optic nerve are mentioned in the ICO guidelines including confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph – HRT), scanning laser polarimetry (GDx Nerve Fibre Analyser – GDx-VCC), and Optical Coherence Tomography (OCT; Figure 8), of which the latter is now the imaging modality of choice. Although structural imaging in isolation using these techniques can differentiate between normal and glaucomatous eyes with mild to moderate visual field loss, none of the current technologies for assessing structural changes of the optic nerve head are suitable for use as an independent screening tool for early to moderate glaucoma or in high risk populations.
Image quality is crucial when assessing structural changes, and it can be difficult to distinguish between glaucomatous structural damage and measurement variability or age-related changes. Furthermore, each technology has its own optical properties and analysis algorithms and therefore the data acquired is not interchangeable between machines. Monitoring advanced disease can be limited by a floor effect, after which no more thinning is observed. The presence of myopia is also associated with structural thinning of the optic nerve and can confound image interpretation when assessing for glaucomatous progression. These technologies should not replace optic disc photography which remains critically important for the recording of optic disc appearance and subsequent monitoring for change with features such as optic disc haemorrhages not being visible with OCT imaging.
Despite these limitations, structural changes can often precede functional losses and provide an earlier marker of glaucomatous change both in diagnosis and when assessing progression, thus providing useful information during the clinical assessment of the optic nerve in glaucoma.