Authors: Anand Sundaralingam, Radhika Banka, Najib M. Rahman
Categories: Review, Chest drain, Effusion, Empyema, Intrapleural enzyme therapy, Intrapleural fibrinolytic therapy, Management, Parapneumonic, Pleural infection
Source: Pulmonary Therapy
Authors: Anand Sundaralingam, Radhika Banka, Najib M. Rahman
Pleural infection is a millennia-spanning condition that has proved challenging to treat over many years. Fourteen percent of cases of pneumonia are reported to present with a pleural effusion on chest X-ray (CXR), which rises to 44% on ultrasound but many will resolve with prompt antibiotic therapy. To guide treatment, parapneumonic effusions have been separated into distinct categories according to their biochemical, microbiological and radiological characteristics. There is wide variation in causative organisms according to geographical location and healthcare setting. Positive cultures are only obtained in 56% of cases; therefore, empirical antibiotics should provide Gram-positive, Gram-negative and anaerobic cover whilst providing adequate pleural penetrance. With the advent of next-generation sequencing techniques, yields are expected to improve. Complicated parapneumonic effusions and empyema necessitate prompt tube thoracostomy. It is reported that 16–27% treated in this way will fail on this therapy and require some form of escalation. The now seminal Multi-centre Intrapleural Sepsis Trials (MIST) demonstrated the use of combination fibrinolysin and DNase as more effective in the treatment of empyema compared to either agent alone or placebo, and success rates of 90% are reported with this technique. The focus is now on dose adjustments according to the patient’s specific ‘fibrinolytic potential’, in order to deliver personalised therapy. Surgery has remained a cornerstone in the management of pleural infection and is certainly required in late-stage manifestations of the disease. However, its role in early-stage disease and optimal patient selection is being re-explored. A number of adjunct and exploratory therapies are also discussed in this review, including the use of local anaesthetic thoracoscopy, indwelling pleural catheters, intrapleural antibiotics, pleural irrigation and steroid therapy.
Parapneumonic effusions are separated into distinct categories according to their biochemical, microbiological and radiological characteristics.It is increasingly recognised there exists heterogeneity within these groups, and there is a paucity of evidence for the optimal first-line intervention, in the form of head-to-head comparator trials.The causative organism varies widely according to geographical location and healthcare setting, and positive cultures are achieved in only 56% of cases. This is expected to increase with next-generation sequencing techniques.Whilst 16–27% of cases managed with tube thoracostomy are expected to require escalation of therapies, treatment success rates of 90% are now reported in the literature with intrapleural enzyme therapy (IET).Future directions will look at delivering personalised therapies according to individual patients’ ‘fibrinolytic potential’ and targeting upstream biochemical pathways.
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Pleural infection is a disease that has plagued both the ancient and modern world [1, 2]. It has been studied and described by the great and the good, but has afflicted them in equal measure. Sir William Osler (1849–1919), hailed as the father of modern medicine, opted for surgical management of his empyema only to succumb to his illness, whilst ironically, the eminent French surgeon Guillaume Dupuytren (1777–1835) opted for conservative measures and eventually met the same fate [3–5]. That we still grapple with some of the same issues our forefathers did serves as a source of both comfort and frustration. Many advances have been made in the management of pleural infection, and in this review, we aim to summarise the evidence to date and outline best practice in the management of empyema in adults. It is important to note that empyema in children is a distinctively different condition from that in adults, and management recommendations for adults do not necessarily apply to children and vice versa.
‘Pleural infection’ is a stepwise progressive condition, classified into stages, and whilst there is some variation in the classification system between different international guidelines, the principles are largely similar. This is summarised in Table 1 and incorporates pertinent features from each of these guidelines.Table 1The varying stages of development of pleural infection [6–8]StagePleural fluid characteristicsRadiological characteristicsStage ISimple exudate ‘uncomplicated parapneumonic effusion’ (UPPE)pH > 7.30Glucose > 60 mg/dL (or > 3.3 mmol/L)Free-flowing effusionStage IIFibrinopurulent‘Complicated parapneumonic effusion’ (CPPE)pH < 7.20Glucose < 35 mg/dL (or < 2.2 mmol/L)LDH > 1000 IU/LNeutrophilicPositive microbiology (gram stain/culture)Presence of pus = ‘empyema’Echogenic effusionTendency towards septations and loculationsStage IIIOrganisingAs aboveVisceral pleural thickeningTrapped lung
Traditionally, it is the presence of pus within the pleural space that earns pleural infection the title of ‘empyema’; however, in the literature, the terms pleural infection, complicated parapneumonic effusion (CPPE) and empyema are used fairly interchangeably, and in clinical practice their management is identical.
It should be borne in mind that pleural fluid biomarkers are simply tests and, like any other, have varying sensitivity, specificity and likelihood ratios. They are not infallible and must be interpreted within the context of the overall clinical picture. Whilst novel pleural fluid markers have been proposed, their discussion is beyond the scope of this review [9–14].
The cornerstones of treatment in pleural infection is prompt evacuation of the infected collection from the pleural space and initiation of antimicrobial therapy [6]. Antimicrobial therapy should be guided by specific pathogen susceptibility. The bacteriology implicated in pleural infection is distinct from that of pneumonia and serves as further evidence of the two as separate clinical entities and hints at differing mechanisms of transmission (e.g. haematogenous route from oropharyngeal sources) [15, 16].
A recent systematic review has shown that pleural fluid culture is positive in only about 56% of cases and is polymicrobial in 12.9%. Within our own institution, our practice is to inoculate blood culture bottles with pleural fluid to further improve the yield. Menzies et al. demonstrated an increase in yield from 37.7 to 58.5% by adopting such simple measures [17]. There is wide variation in causative organism according to geographical location and the healthcare setting of infection (Table 2). In a recent systematic review encompassing 75 studies and more than 10,000 participants, Staphylococcus aureus (20.7%) appears to have overtaken the Streptococcus viridans group (18%) as the most commonly cultured pathogen globally [18]. Hitherto, Streptococcus milleri, the most common subgroup of S. viridans, was thought to be the commonest isolate [6, 19]. While the tropics and temperate regions had a greater incidence of Gram-positive organisms, subtropical regions had a higher incidence of Gram-negative bacteria. Community-acquired infections were often caused by Gram-positive aerobes (65%), whereas within hospital-acquired settings, Gram-negative aerobes had the larger share (38%). With the advent of next-generation techniques such as 16S ribosomal RNA (rRNA) sequencing and whole-genome sequencing (WGS), we may overcome some of the deficits of standard microscopy and culture techniques. With these techniques, prior antibiotic usage is unlikely to affect yield, polymicrobial infection will be more readily identified, and the impact of fastidious organisms in pleural infection, previously rarely cultured, will be realised [19]. Although this runs the risk of opening up a minefield of interpretation and management decisions, it will likely advance our understanding of the pleural microbiome, in disease and in health.Table 2Isolated bacteria from pleural fluid in community-acquired vs hospital-acquired pleural infection in descending order of frequency [18]Community-acquiredHospital-acquiredViridans StrepStaph aureus (MRSA)Strep pneumoniaeEnterobacteriaceaeStaph aureus (MSSA)EnterococciEnterobacteriaceaeViridans StrepKlebsiellaPseudomonasPseudomonasKlebsiella
In culture-negative pleural infections, empirical antimicrobial therapy should be based on local resistance patterns and antimicrobial stewardship policies [18]. The British Thoracic Society (BTS) and American Association for Thoracic Surgery suggest broad-spectrum antibiotics with Gram-positive, Gram-negative and anaerobic cover until culture and sensitivities are available [6, 8]. In pneumococcal infections, anaerobic cover is rarely required; as Maskell et al. demonstrated across 74 such infections, there was not a single instance of anaerobic co-infection [20]. For pleural infection secondary to community-acquired pneumonia, where the risk of methicillin-resistant Staphylococcus aureus (MRSA) or Gram-negative bacteria is low, a second- or third-generation cephalosporin combined with metronidazole or penicillins combined with a β-lactamase inhibitor (e.g. co-amoxiclav) is recommended. Clindamycin is a suitable alternative to metronidazole for anaerobic cover [21]. Additional MRSA cover is recommended in the setting of hospital-acquired infections, as close to 60% of all S. aureus in this setting is likely to be an MRSA [18]. Since the prevalence of Mycoplasma spp. and Legionella spp. in pleural infection is low, routine use of atypical cover is not recommended [6, 20].
The penetration of antibiotics into the pleural space is an area of much debate. In a rabbit model, most antibiotics with the exception of aminoglycosides have demonstrated good penetration into the pleural space [22]. There are no data, however, on the concentration or bioavailability of antibiotics within the human pleural space. Animal studies have shown higher levels of fluoroquinolones in pleural fluid than in blood at 4–12 h after administration, and the presence of clarithromycin in pleural fluid inhibited most empyema-causing organisms [23, 24]. However, the applicability of these findings in humans is unknown. Further research on antibiotic concentrations in human pleural fluid is essential to improving rates of antibiotic failure in pleural infection [22, 25].
The duration of antimicrobial therapy in pleural infection is an evidence-free zone and is largely based on expert opinion and extrapolation from recommendations for the treatment of lung abscess. The recommended duration varies from 2 to 6 weeks, and the authors recommend a minimum of 4 weeks (in total, including intravenous and oral treatment) [26]. Current BTS guidelines recommend switching from intravenous to oral antibiotics when there has been clinical improvement with cessation of pyrexia, resolution of inflammatory markers and radiological improvement [6]. A retrospective study involving 91 patients showed that 3 weeks of antimicrobial therapy was usually adequate to prevent treatment failure [27]. With more definitive treatment options for treating pleural infection with intrapleural enzyme therapies (IET) and surgery, there may be a further argument for shorter-duration antibiotic regimes. The rising importance of antibiotic stewardship highlights the urgency for prospective well-designed trials to define optimal antibiotic duration.
The earliest accounts of ‘open thoracic drainage’ date back to the ancient Greeks [28, 29]. Despite the significant risk of mortality as a result of an open pneumothorax, this remained the standard of care for centuries. Although ‘closed tube’ drainage systems had been well described by the German physician Dr. Gotthard Bülau in 1891, they only began to feature more consistently following the ‘Empyema Commission’ during World War I. Coinciding with the Great H1NI influenza pandemic, this resulted in a surge in cases of streptococcal empyema, with a mortality rate of 30% in military hospitals. Through the efforts of Dr. Evarts A. Graham and the commission, the mortality rate was reduced to 3.4% with the adoption of some simple measures as described in Fig. 1 [30].Fig. 1Annotated from Graham’s ‘Some fundamental considerations in the treatment of empyema thoracis’, 1925
Through his seminal body of work, Dr. Richard Light and collaborators demonstrated the need for ‘closed tube’ drainage in only those parapneumonic effusions we would now classify as belonging to the ‘fibrinopurulent’ stage [31–33]. This case series demonstrated the favourable outlook for uncomplicated parapneumonic effusion (UPPE), which often resolved with antibiotic use alone and has now become the standard of care [6–8, 19, 34]. It should however be noted that these large case series have not examined outcomes of UPPE in detail.
It is important to reassess the clinical picture if the patient makes no improvement, and this may require resampling of the pleural fluid. Some patients with an UPPE will progress to a CPPE despite prompt antimicrobial use; a proposed explanation is the heterogeneous nature of pleural fluid within loculated collections, and sampling from one locule may not be representative of the remainder [35]. Therefore, tube drainage for multi-loculated collections is also recommended, irrespective of pleural fluid characteristics [6, 7].
It is worth discussing the role of therapeutic aspiration in pleural infection. This was used extensively in the series by Light et al. as a combined diagnostic/therapeutic intervention and for effusion recurrence. Pragmatically, the use of large-volume aspiration as part of the initial diagnostic procedure for stage I infection would seem reasonable, particularly with large effusions where it is likely to provide symptomatic relief. Interestingly, Porcel et al. demonstrated in their retrospective case series of 641 patients that effusions that occupied one-half or more of the hemithorax strongly correlated with a CPPE and were likely to need tube drainage, independent of other pleural fluid characteristics [36]. Repeated thoracocentesis has been described in some case series and a single prospective observational study with reasonable rates of success (76% success, median 3 procedures), but prospective randomised controlled trial (RCT) data is lacking [37–41]. With the advent of small-bore catheters and minimally invasive techniques, tube drainage has largely superseded this technique, and most experts would agree that the risk of repeated entry into the pleural space outweighs that of a single, more definitive intervention [42]. Therefore, when dealing with a large parapneumonic effusion, tube drainage is recommended over multiple aspirations [6, 7, 36]. As we move into the era of ambulatory management of many conditions, spurred by the current COVID-19 pandemic, this is an area ripe for research. Indeed, there is a currently recruiting trial addressing this potential treatment option in the UK (ISRCTN84674413) [43].
Following on from this, the optimal size of intrapleural catheter in treating empyema is yet to be defined. It remains a topic of great interest and is regularly a source of debate at conferences and in editorials [44]. Medical dogma has suggested larger-bore drains to be more efficacious in managing empyema, but a number of retrospective case series have demonstrated success with small-bore drains [45–55]. The only study comparing differences in outcome between small- and large-bore drains in a prospectively recruited cohort comes from our unit [56]. This retrospective analysis of the MIST-1 trial data included 405 patients and demonstrated no difference in clinical outcomes by drain size (mortality or the need for surgery) or in adverse event rates, with a drain displacement rate of 17–23%. Importantly, this study noted a marked difference in pain scores; large-bore drains (> 14F), particularly those inserted via blunt dissection, were associated with a significantly higher pain score compared to small-bore drains (≤ 14F) [56, 57]. Furthermore, in subgroup analysis of the MIST-2 trial data, no difference in treatment effect was noted between large- and small-bore drains [58]. Though prospective data on drain outcomes specific to empyema are lacking, estimates from case series suggest drain occlusion rates as high as 63% and that regular saline flushes can mitigate this [8, 55, 59, 60]. This concept was taken further in the single-centre RCT ‘Pleural Irrigation Trial’ (PIT), which saw improvements in the volumes of pleural collection on CT and referral to surgery in the intervention arm receiving 250 ml 0.9% sodium chloride three times a day.
The authors prefer the term IET (rather than intrapleural fibrinolytic therapy, IPFT) as a catch-all term, and such treatment is a relatively old concept. It has long been recognised that as infected pleural fluid became more frankly purulent, it had a tendency to loculate and become more viscous, thereby making drainage difficult [61]. Indeed current evidence suggests that some 16–27% of patients treated with antibiotics and tube drainage alone will go on to require further surgical intervention to treat their pleural infection, whilst older studies quote even higher rates [57, 58, 62, 63].
Tillet and Sherry, through their pioneering work 70 years ago, recognised that it was the presence of fibrin and ‘deoxyribose nucleoprotein’ (DNA) that contributed to the purulence and viscosity of post-haemothorax pleural infection. Their attempts to overcome this problem and increase the effectiveness of tube drainage through the use of intrapleural streptokinase and deoxyribonuclease (DNase) paved the way for wider use of these agents [64–66].
Although the duo demonstrated in 1949 that it was the combined effects of both streptokinase and DNase that improved drainage, the latter fell out of use particularly in North America, perhaps borne out of concerns surrounding allergic reactions to the combined preparation, originally extracted from haemolytic group C streptococci [61, 64].
IPFT as sole therapy has been studied extensively through case series and RCTs, but perhaps the most robust answer comes from a Cochrane review by Altmann et al. Across 10 RCTs encompassing 993 participants, there was no difference in mortality observed between the IPFT and placebo group, but a reduction in surgical intervention and treatment failure was seen in the IPFT arm (OR 0.37, 95% CI 0.21–0.68 and 0.16, 95% CI 0.05–0.58, respectively). However, in sensitivity analysis, removing studies at high risk of bias eliminated these benefits. Importantly, the largest study (MIST-1: streptokinase vs placebo, 427 participants), also deemed to be at low risk of bias, was discordant with these findings [67]. It is important to note that the studies analysed in this latest systematic review represent both a heterogeneous population (MIST-1 recruited all patients with a diagnosis of pleural infection, whilst others specified patients with radiological evidence of loculation or failure to progress with tube drainage) and heterogeneous measured outcomes [57, 58, 62, 63, 68–75].
Adding further to the discussion came MIST-2 (210 participants), which demonstrated outcome benefit, measured through radiological clearance, surgical referral and length of stay when comparing combination tissue plasminogen activator (t-PA) and DNase to placebo and, importantly, to either individual agent alone [58]. Though an oversimplification, it is proposed that IPFT acts to disrupt the fibrin-rich adhesions via the activation of plasminogen and may have something of a lavage effect by stimulating pleural fluid production, whilst DNase reduces pleural fluid viscosity through the breakdown of extracellular DNA and biofilm formation. It is their synergistic action that results in better drainage and resolution of pleural infection [66, 76–81]. These findings build on the earlier work by Tillet and Sherry but also go some way in confirming other proof-of-concept studies [61, 64, 82, 83]. This has now become the standard of care for non-draining pleural infection in many centres, and there is an increasing body of evidence to demonstrate both efficacy, with treatment success rates of 90%, and safety, with an adverse event bleeding rate of < 5% [84–88]. Importantly, many of these subsequent studies have successfully incorporated their own dose adjustment regimes, highlighting the potential for precision-guided personalised medicine in treating pleural infection (Fig. 2).Fig. 2The fibrinolytic pathways involved in relation to IET therapies and some novel therapeutic targets (in green are some currently developed PAI-1-neutralising antibodies, scuPA (also known as LTI-01) [89, 93–95]. PAI plasminogen activator inhibitor, scuPA single-chain urokinase plasminogen activator, tPA tissue plasminogen activator, LTA lipoteichoic acid
The development of IET regimes has occurred outside the usual drug development cycles observed in industry-led trials, and therefore much of the pharmacological insight a phased development process produces and that which precision medicine hinges upon has eluded us until recently [76, 89]. It is increasingly recognised that pleural infection is a form of tissue injury with subsequent activation of the clotting cascade, and understanding the delicate balance of the coagulation and fibrinolysin pathway, and by extension the ‘fibrinolytic potential’, is essential in advancing management [78, 79, 89–91]. Figure 2 describes some of these pathways and some novel therapeutic targets, one of which has a phase II study planned (NCT04159831) [92].
Surgery has long been recognised as a cornerstone in the management of pleural infection, and this is reflected in all major society guidelines. Its precise role remains unclear, which gives rise to variation in the recommendations, with much of the debate revolving around patient selection [6–8, 96]. Some guidelines suggest all cases of empyema in stage II or greater be offered surgical management due to greater rates of treatment success and reduced length of hospital stay [96–99]. This fails to recognise some of the recent advances made in IET and the impressive rates of treatment success across a spectrum of empyema stages, with reports nearing 90% in expert centres [58, 84–86, 88]. The truth most likely resides somewhere in the middle, and the fairly crude separation of the stages of empyema into I, II and III in determining optimal first-line therapy runs the risk of ignoring important considerations; these are not always binary categories; there exists a spectrum of abnormality, and other differentiators also play a role [100]. The old adage that surgery be reserved for those that fail conventional medical therapy is seemingly intuitive. Despite this, a large retrospective population-based observation study demonstrated much higher levels of mortality for patients managed non-operatively, even after adjusting for differences in age and comorbidity (11.1% 30-day mortality vs 3.3%), and this finding is supported by other retrospective studies [101–103]. What is clear, however, is the distinct lack of head-to-head, prospective data to settle this debate [19, 26]. Even a recent Cochrane review into the question could only produce 8 trials across 391 participants, of which 6 trials were within a paediatric population. Their conclusion of no statistical differences in mortality between the surgically and non-surgically managed groups must therefore be interpreted with caution, given paediatric empyema is a clinically distinct entity with very different outcomes and microbiology [104]. Offering early aggressive treatments such as surgery, with the risks this entails, needs to be balanced against the risks associated with empyema in the first instance. The RAPID score was derived from the MIST-1 cohort and then validated in the MIST-2 cohort. The score is based on baseline serum urea (renal), patient age (age), pleural fluid purulence (purulence), infection source (community- vs healthcare-acquired infection) and serum albumin (dietary), and was shown to be independently associated with mortality at 3 months [105]. Now this score has been validated prospectively in the Pleural Infection Longitudinal Outcome (PILOT) study. Across 546 patients, the PILOT study demonstrated that low-risk patients (RAPID score 0–2) had a 3-month mortality of 2.3%, medium-risk (RAPID score 3–4) 9.2% mortality and high-risk (RAPID score 5–7) 29.3% mortality [106]. It is hoped that through the use of the RAPID score, a more nuanced approach can be taken in risk-stratifying patients and thereby informing clinicians of the optimal approaches in management.
Conceptually, surgical options for the management of empyema centre on debridement and evacuation of the infected material from the pleural space. Where the visceral pleura has developed a thickened rind, a decortication is also required to allow for lung re-expansion, crucial for maintaining a sterile pleural space thereafter. These procedures can be performed through a less invasive video-assisted thoracoscopic surgical (VATS) approach or a more invasive open thoracotomy approach [100, 107]. In comparing the two approaches, VATS has certainly been shown to have more favourable rates of complications, morbidity, mortality (in-hospital 5.7% vs 10.6%) and length of hospital stay (5 vs 8 days) whilst retaining similar efficacy as that of the open approach [96, 99, 101, 108, 109]. Whilst it would therefore seem obvious to opt for a VATS approach, and there is a clear trend towards this over the years, the reality is not quite so straightforward. There are technical difficulties in a VATS approach in late-stage empyema; dense adhesions can prevent insertion of the thoracoscope, or complete decortication may not be possible due to the location and depth of peel formation [110]. In such situations, there is a need to convert to an open thoracotomy approach, and conversion rates as high as 55% have been reported in the literature [111]. More modern studies still have a conversion rate of around 15% [100]. Inability to tolerate single-lung ventilation or severe coagulopathy are also considered contraindications to a VATS approach. Although conversion is associated with an increase in intra-operative time, it is not clear whether this has an effect on outcome [112]. Some experts argue that a thoracoscopic view of the pleural cavity via VATS may indeed be a necessary step in determining the need for an open approach [110]. The role of non-invasive investigations such as computed tomography (CT) in making these decisions has had mixed results [113–115]. What is clear in the literature, however, is that delays in surgical intervention are consistently the strongest predictor of the need for conversion [116, 117]. Therefore, offering surgical intervention only in cases of failed medical therapy, with its subsequent delays, or in late-stage empyema and thereby precluding patients from receiving the gold-standard surgical intervention, would seem something of a paradox [19, 118]. It is this paradox that experts are now grappling with and that has set the stage for head-to-head trials of early VATS vs early IET vs standard care with the MIST-3 feasibility study (ISRCTN18192121) [119].
It is worth briefly mentioning other therapies that are either currently in use or on the horizon. Local anaesthetic thoracoscopy (LAT) has been used in the management of pleural infection, but currently sits outside the recommended guidelines [120]. It has been suggested that LAT has utility in clearing septations and allows for targeted drain insertion, although it seems unlikely to be of use in the advanced stages of empyema. In the hands of experienced operators, excellent outcomes have been reported in case series, but LAT has never been studied in head-to-head comparator trials. The ‘Studying Pleuroscopy in Routine Pleural Infection Treatment’ (SPIRIT) trial (ISRCTN98460319) was a feasibility study and is due to publish results later this year [121].
A chronically infected pleural space with a trapped lung is a challenging condition. In particularly advanced cases where patients are not fit enough to undergo decortication, the only surgical options may be limited to thoracoplasty or open window thoracostomy [107]. In the modern era, these techniques report reasonable rates of success (75–95%) and mortality (4%), aided further by the use of vacuum-assisted closure (VAC) techniques [100]. However, many patients are often not fit enough to undergo surgical intervention or have associated co-morbidity (e.g. malignant pleural disease) that precludes such treatments. In such cases, prolonged antibiotic therapy and the use of an indwelling pleural catheter (IPC) have been described in limited case reports [122]. It is important to note that this approach has not been validated through trial data, nor is it likely to be, given the small numbers of such patients. Broadly speaking, pleural infection remains a contraindication to IPC insertion and a complication thereof [26]. However, this treatment approach offers an alternative to repeated tube thoracostomy and may facilitate a more holistic approach to caring for patients on a palliative pathway.
Intrapleural antibiotic therapy has often been proposed as a way of overcoming the poor pleural penetrance seen with a number of antibiotic classes. A recent review found little evidence to support the routine use of these therapies in post-pneumonic pleural infection, although there is more evidence for its use in post-pneumonectomy infections [80]. A number of antibiotic-eluting drainage catheters are now commercially available, and a recent study was able to demonstrate sustained release of bactericidal concentrations of penicillin within the pleural space compared to an intravenous regime in healthy rabbits [123]. What effect this technique has in animal models of empyema remains to be seen before human studies can be considered.
Finally, whilst many of the treatment modalities described in this review have centred on optimal evacuation of infected pleural fluid, there is a body of work exploring methods to ‘switch off the leaky faucet’ [76]. Key inflammatory mediators [NF-κB, CCL2/MCP-1, TNF, interleukins, osteopontin (OPN)] have been identified and there is clear overlap with the processes involved in malignant pleural effusion formation. Whilst this work is still in its infancy and targeted pharmacotherapy is not yet on the horizon, it is thought that systemic steroids may attenuate some of these pathways. Its safety in pneumonia has already been demonstrated as well as a signal towards clinical efficacy [124, 125]. With the aim of combatting the exaggerated inflammatory cascade seen in pleural infection, the ‘Steroid therapy and outcome of parapneumonic pleural effusions’ (STOPPE) trial (ACTRN 12618000947202), is currently recruiting patients into a pilot multi-centre RCT, comparing 48 h of intravenous dexamethasone to placebo [126].
The management of pleural infection has come a long way from ancient descriptions and has enjoyed something of a renaissance in the past decade. The key areas the next decade hold include identification and refinement of targeted therapies in both early- and late-stage disease processes and finally establishing optimal first-line therapies.