Authors: Alka Sharma, Sourabh Aggarwal, Vishal Sharma
Categories: Case Report, Anemia, bitot's spots, celiac, malabsorption, malnutrition, vitamin A
Source: International Journal of Preventive Medicine
Vitamin A deficiency (VAD) can cause a range of ocular manifestations, including night blindness, conjunctival and corneal xerosis and keratomalacia. It is an important cause of preventable blindness. Although usually a result of malnutrition, VAD can accompany malabsorption syndrome. We report a case of VAD as manifested by Bitot's spots and eventually diagnosed to have celiac disease. It is, therefore, important to consider gastrointestinal diseases causing malabsorption in the evaluation of VAD.
Keywords: Anemia, bitot's spots, celiac, malabsorption, malnutrition, vitamin A
Vitamin A is a fat soluble vitamin which is made of a family of compounds called the retinoids. The deficiency of vitamin A may manifest with difficulty in night vision, dry skin, and hair. Whilst the most common cause of vitamin A deficiency (VAD) is malnutrition, any gastrointestinal disorder causing malabsorption of lipids can also result in VAD.
A 10-year-old boy presented with diarrhea since 1 year. He used to pass multiple stools in a day. He also complained of decreased vision in low lighting. The child was malnourished, had pallor and height for age and weight for age were lower than the 3^rd^ percentile. He was eldest of the three siblings and belonged to a poor rural family. He also had superficial, irregularly-shaped, white lesions on the conjunctiva in both eyes [Figure 1]. Mild pitting pedal edema was noted and systemic examination was normal. Evaluation revealed low hemoglobin of 8 mg/dL (Normal 12-16 mg/dL), microcytes in peripheral smear and a mean corpuscular volume of 71 mm^3^, normal leukocyte count and thrombocytosis (5 lakh/mm^3^). The patient had low serum albumin (2.8 g/dL, Norma: 3.5-5 g/dL) and mild transaminitis (Alanine transaminase - 71 U/L, Normal: 0-35 U/L, aspartate transaminases AST- 75 U/L, 7-41 U/L) with a normal level of bilirubin. The work-up for cause of transaminitis including viral markers (surface antigen for hepatitis B and antibodies to hepatitis C virus) were nonreactive. Upper gastoduodenoscopy showed grooving and scalloping in second part of duodenum. Duodenal biopsy revealed subtotal villous atrophy. immunoglobulin A (IgA) tissue transglutaminase was 213 U/mL (Normal: 0-8 U/mL).
Figure 1 Bitot's spots
Eponymsed after Charles Bitot who first described them, Bitot's spots represent an ocular manifestation of VAD.[1] VAD is an important cause of preventable blindness in the developing world. Clinical detection of Bitot's spots affords an opportunity for early diagnosis of VAD. Although VAD may have disappeared in the developed world, the condition is still common in the developing world. Since determination of levels of serum retinol are not available routinely ocular features ranging from night blindness, conjunctival xerosis and corneal xerosis, Bitot's spots and corneal ulceration and scarring may provide clinical clue to the diagnosis.
Lack of vitamin A affects the development of goblet cells in the conjunctiva resulting in accumulation of keratin debris. The Bitot's spots also demonstrate keratinization, irregular maturation, inflammatory infiltration and accumulations of Gram-positive bacilli.[2] Generally seen as triangular spots, the Bitot's spots usually have the tip laterally and may have a variable surface. These may be foamy and cheesy whitish lesions and are the most common indicator used to estimate VAD in community.[3] Bitot's spots are usually due to nutritional VAD which is a common public health problem among preschool children in the developing world.[4] Other conditions associated with systemic avitaminosis A may include reduced intake (alcoholism, mental illness, and dysphagia), disordered absorption (Crohn's disease, celiac sprue, pancreatic insufficiency, and short bowel syndrome), disordered transport (Abetalipoprotenemia) and reduced storage (liver disease).[5] The clinical detection of Bitot's spots confirms VAD. Confirmation may be done by estimation of serum retinol or retinol binding protein levels. The efforts should be directed to evaluate the cause of VAD including reduced intake or any malabsorptive state. In the present case, a diagnosis of celiac sprue was established and patient put on gluten free diet with improvement in form of normal stool frequency and a gain of height and weight. The IgA tissue transglutaminase at 6 months was 3.8 U/mL.