Authors: Lili Qiao, Xiucen Wu, Guihua Chen, Huan Tang, HuaPeng Shen
Categories: Review, pre-COPD, chronic obstructive pulmonary disease, COPD, risk factors, incidence, meta--analysis
Source: International Journal of Chronic Obstructive Pulmonary Disease
Doi: 10.2147/COPD.S566518
Authors: Lili Qiao, Xiucen Wu, Guihua Chen, Huan Tang, HuaPeng Shen
Pre-chronic obstructive pulmonary disease (Pre-COPD) refers to individuals who do not meet traditional diagnostic criteria for COPD but already show respiratory symptoms, abnormal lung function, or imaging changes. The purpose of this study was to complete a systematic review and meta‑analysis of the incidence and risk factors for progression from pre‑COPD to COPD.
We searched ten databases through December 31, 2024. The Newcastle–Ottawa Scale (NOS) was applied to assess the methodological quality of the eligible studies. We extracted incidence to quantify progression from pre-COPD to COPD and odds ratios (ORs) and hazard ratios (HRs) with their 95% confidence intervals (CIs) to identify associated risk factors. Effect sizes were pooled using fixed-effects and random-effects models.
Among 5289 articles, 21 were eligible, and 13 reported incidence. The pooled incidence of progression from pre-COPD to COPD was 20% (n = 13, 95% CI 15–26%). We identified five statistically significant factors linked to clinical development in pre-COPD: preserved ratio impaired spirometry (PRISm) (ORs=2.92, 95% CI 1.79–4.74), age (ORs=1.09, 95% CI 1.03–1.15), smoking history (ORs=4.08, 95% CI 2.14–7.18, HRs=2.21, 95% CI 1.59–3.07), non-obstructive chronic bronchitis (NOCB) (ORs=2.07, 95% CI 1.32–3.24, HRs=2.46, 95% CI 1.61–3.75), and asthma (ORs=2.50, 95% CI 1.93–3.24).
This meta-analysis indicates a high incidence of progression from pre-COPD to COPD. Moreover, age, smoking history, NOCB, PRISm, and asthma were significantly associated with an increased risk of clinical progression in individuals with pre-COPD. Integrating these risk factors into clinical risk-stratification tools and follow-up strategies may help clinicians identify high-risk individuals with pre-COPD, facilitating enhanced surveillance, targeted smoking cessation interventions, optimized asthma management, and other preventive interventions to delay or prevent COPD onset.
Chronic Obstructive Pulmonary Disease (COPD) is the third most common cause of death worldwide, and it represents a significant global health challenge, with high rates of both morbidity and mortality.1,2 As awareness of disease prevention and early intervention grows, numerous studies indicate that ultra-early intervention may enhance the long-term prognosis for COPD patients. In recent years, multiple cohort studies have demonstrated that lung function indices alone are insufficient to define COPD completely; Instead, risk factor exposure, respiratory symptoms, and structural alterations, as evidenced by imaging (CT), should also be considered essential components of its diagnostic framework.3–5 In this context, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2022 proposed the concept of pre-COPD (pre-chronic obstructive pulmonary disease) for the first time.6 It refers to individuals exhibiting respiratory symptoms, structural lung abnormalities, or physiological dysfunctions of the respiratory system, who do not satisfy the diagnostic criteria for airflow limitation.2,7
Pre-COPD includes various clinical subgroups, such as preserved ratio impaired spirometry (PRISm), non-obstructive chronic bronchitis, emphysema, diminished diffusion capacity (DLCO), and a rapidly declining forced expiratory volume in one second (FEV1).7 Epidemiologic data show that the estimated prevalence of pre-COPD in the population ranges from 7.2% to 22.3%,8,9 with regional variations in prevalence, and that a significant majority of patients are at risk of progressing to COPD over time. The large international COPDGene and SPIROMICS cohorts have demonstrated that approximately 40–50% of the pre‑COPD population exhibit symptom profiles similar to those of mild COPD, and these include emphysema, airway collapse, airway wall thickening, and elevated airway mucin levels.10,11 Moreover, over 23.5% of persons with pre-COPD demonstrate diminished quality of life and exercise capacity, and 54.1% display one or more respiratory-related functional deficits.10 An increasing volume of research indicates that pathological processes, including lung parenchymal injury, structural alterations in small airways, and mucus hypersecretion, may already manifest in the pre-COPD stage, subsequently facilitating airway remodeling and irreversible airflow limitation.12–14 Studies indicate that by the time extensive airway injury fulfills the diagnostic criteria for established COPD, up to 50% of small airways may already have been destroyed.15 The biological basis of progression from pre-COPD may involve multiple mechanisms, such as oxidative-stress-induced epithelial injury and the initiation of epithelial-mesenchymal transition (EMT), which in turn lead to airway wall thickening, scar formation, and progressive small airway narrowing or obliteration.16 Research has found that features of EMT observed in patients with established COPD are also present in smokers who are at the pre-COPD stage.17 Additionally, genetic susceptibility quantified by polygenic risk scores and early immune programming is thought to partially account for the heterogeneity in the risk of disease progression.18,19
While initial studies have elucidated the clinical characteristics and progression rate of Pre-COPD, variations in study design, duration of follow-up, and testing methodologies have led to significant heterogeneity in reported findings, precluding the formation of a unified and systematic body of evidence. Early screening and intervention for pre-COPD, a critical high-risk group for COPD development, can delay or prevent the onset of COPD. This will reduce the disease burden and optimize the allocation of healthcare resources. This work consolidates existing cohort data by systematic review and meta-analysis to estimate the incidence of pre-COPD progression to COPD and to summarize its principal risk factors, aiming to establish a scientific foundation for pre-COPD preventive and treatment strategies.
This systematic review was registered with PROSPERO (CRD42025637741). We utilized the revised criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA 2020) for our research.20
We performed a comprehensive literature search throughout PubMed, Web of Science, Embase, OVID, the Cochrane Library, ProQuest, CNKI, Wan Fang Database, VIP Database, and the Chinese Biomedical Literature Database from their establishment until December 31, 2024. We first developed a search strategy for PubMed and simultaneously searched the other databases with similar terms. We used the following Medical Subject Headings terms and free (“Pre-COPD” OR “pre-chronic obstructive pulmonary disease” OR “early COPD” OR “early chronic obstructive pulmonary disease*” OR “early chronic pulmonary disease” OR “early chronic obstructive lung disease*”) AND (“risk*” OR “risk factor” OR “influencing factor*” OR “predictive factor*” OR “predictor*” OR “predict factor*” OR “influence factor*” OR “influential factor*” OR “affecting factors” OR “correlation factor”). Reference lists from identified studies and relevant review articles were also searched for studies eligible for inclusion.
The inclusion criteria were as follows; 1) were observational in design, including retrospective and prospective studies; 2) the study population comprised individuals presenting with respiratory symptoms, structural lung lesions, or abnormal pulmonary function who did not meet the diagnostic criteria for airflow obstruction;6 3) the primary outcome of interest was the development of chronic obstructive pulmonary disease (COPD) during follow-up. These outcomes should align with recognized diagnostic criteria or be diagnosed by a physician; 4) exposure factors were delineated as distinct elements or conditions recognized in the research as potential contributors to heightened progression risk.
Studies were excluded for the following 1) studies did not report risk estimates, including relative risks (RRs), hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) or raw data in an appropriate format to calculate an effect size; 2) commentaries, conference abstracts, and reviews; 3) the language of the publication was other than English or Chinese. Two researchers (QLL and WXC) independently screened the titles and abstracts of eligible articles identified using the aforementioned search strategy. After duplicate articles were removed from the list of eligible articles, full texts of the remaining articles were reviewed to determine whether they met the predetermined inclusion criteria. Any disagreements were resolved through discussion or, if necessary, consultation with a third evaluator (TH).
Two independent investigators (QLL and WXC) extracted data from the included studies. Disputes were settled through dialogue or by a third investigator where required. All extracted data were preserved in a uniform Microsoft Excel spreadsheet format. The recorded information includes the first author’s name, publication year, country, setting, design, age, sample size, gender, pre-COPD follow-up population, follow-up durations, COPD incidence, and clinical risk factors for pre-COPD progression.
Two researchers (QLL and WXC) independently assessed the quality of the final included literature using the Newcastle-Ottawa Scale(NOS),21 which consists of eight items. A score of ≥6 indicates moderate to high quality of the literature.22 The detailed Newcastle–Ottawa Scale quality assessment results are provided in Additional Table 1.
All analyses were conducted utilizing the comprehensive meta-analysis program, Stata 18. A random-effects model was employed to aggregate the incidence of progression from pre-COPD to COPD, along with the associated 95% confidence interval (CI). Secondly, we employed meta-analysis to investigate the risk factors associated with pre-COPD development using adjusted effect estimates (ORs or HRs). We performed a systematic review of all individual yet relevant factors. The adjusted odds ratios (ORs), hazard ratios (HRs), and their respective 95% confidence intervals (CIs) were aggregated utilizing fixed-effects or random-effects models. A two-tailed p-value less than 0.05 was deemed significant. If relevant factors were consistently recorded, they were aggregated in a meta-analysis. The I-square test statistic (I^2^) was utilized to evaluate study heterogeneity. Medium or high heterogeneity was deemed present when I^2^ exceeded 50% or 75%, and p-values were below 0.05, respectively.23 Random models were adopted to synthesize the risk effects if heterogeneity was medium or high. Funnel plot and Egger’s test were used to evaluate the publication bias of research results.
To explore potential sources of heterogeneity in incidence, we performed subgroup and sensitivity analyses on the included studies. The incidence of progression from pre-COPD to COPD, with corresponding 95% confidence intervals, was calculated for subgroups according to country (Western vs Eastern), follow-up duration (< 5 years vs ≥ 5 years), publication year (Pre-2022 vs Post-2022), study design (prospective cohort vs retrospective cohort), and pre-COPD sample size (< 100 vs 100–500 vs ≥ 500). Meta-regression was not possible because there were fewer than 10 studies for each covariate.
Overall, 5,289 reports were identified through PubMed, Web of Science, EMBASE, Ovid, the Cochrane Library, ProQuest, CNKI, Wanfang, VIP, and the China Biomedical Literature Database. After excluding 1,131 duplicate records, the remaining 4,158 studies were screened by title and abstract, excluding 4,051 irrelevant records. Five additional studies were excluded due to unavailable full texts, leaving 102 reports for full-text assessment. Of these reports, 84 were excluded for the following non-cohort design (n = 47), non-English/Chinese publication (n = 5), and no relevant outcome data on COPD incidence and/or risk factors (n = 32). We additionally identified three studies after searching the reference lists of the included studies, which expanded our list of eligible studies to 21 (Figure 1). Given the considerable heterogeneity in terminology and at-risk populations across studies, the operational definitions of pre-COPD-related at-risk groups in each included study are summarised in Additional Table 3. Figure 1The study flow diagram.3,24–43
The characteristics of the included studies are shown in Table 1. The 21 studies included 17 prospective cohort studies3,24–39 and 4 retrospective cohort studies.40–43 The studies were from eight countries (the US, the UK, Japan, the Republic of Korea, Croatia, Australia, Denmark, and China). Of them, the majority took place in the US (n = 9) and the Republic of Korea (n = 3), followed by China (n = 2), the UK (n = 2), Denmark (n = 2), Japan (n = 1), Australia (n=1), and Croatia (n = 1). The majority (71.4%) were multicenter studies. These studies involved a total of 417,066 participants. The methodological quality of the included research is assessed by the NOS. All included studies achieved Newcastle Ottawa Scale scores of 6 and above, indicating moderate-to-high quality.
Table 1Detailed Characteristics of Included StudiesAuthor (Year)CountryStudy DesignSettingAgeSample SizeMales (%)Jing Fan (2024)24ChinaPMulticenter≥40352642.2Yunus Çolak (2024)25DenmarkPMulticenter20-50549740.2Žarko Vrbica (2023)26CroatiaPMulticenter40-6532041.9Miguel J. Divo (2023)27USPMulticenter40-75150733.2Ben-Gary Harvey (2015)28USPSingle-center41-591570NAHye Jung Park (2018)29South KoreaPMulticenter≥40266693.8Yong Suk Jo (2024)30South KoreaPMulticenter40-69476250.3Ding S Bui,(2018)31AustraliaPSingle-center7-53243848.4SpyridonFortis (2020)32USPMulticenter45-80113145.8Mehrdad Arjomandi (2019)33USPMulticenter40-80618NAStefani Guerra (2009)34USPSingle-center21-80141241.5Nathan Yee (2022)35USPMulticenter40-8083248.6Daniel H Higbee (2022)36UKPMulticenter40-6935187446.3Yunus Çolak (2021)3DenmarkPMulticenter20-10014870NARussell G. Buhr (2022)37USPMulticenter51-7377846.5Fan Wu (2024)38ChinaPMulticenter20-80114058.5Raina Kanetake (2022)40JapanRSingle-center56.5±9.5167258.4Lystra P. Hayden (2015)42USRMulticenter45-801015653.4NaraTagiyeva (2016)39UKPSingle-center10-152511NADo Sun Kwon (2020)43South KoreaRSingle-center>4030747.2Siyang Zeng (2019)41USRMulticenter>40747992.5Pre-COPD Follow-Up PopulationFollow-Up DurationsResultIncidence of COPDRisk FactorsNA3.59 yearsNAsSAD, NOCB73910 years28%PRISm, Early airflow limitation, Asthma, NOCBNA2.1 yearsNAMale sex, EBTd, Dyspnea2736.3 yearsNASmoking history, FEV1/FVC<0.75, NOCB, BMI≤25 kg/m^2^4641±31 months22%Low DLCO3133 years5.11%Age, Wheezing9322 years5.04%PRISm, pre-COPD99546 years10.55%Early below average FEV1 with accelerated decline, Persistently low FEV1, Below average FEV16175 years25%Low FVC/TLCct4962.7 years16.7%High RVct/ TLCct9722 yearsNASmoking history, NOCBNA48-50 monthsNALow FEV3/FEV619739 years12%Age, Asthma16810 years12.5%Smoking history1757 years61%VO1341 years29.9%VO17634.73±10.77 months6.25%Smoking history, PRISm, Low BMINANANAChildhood pneumonia, Childhood pneumonia with comorbid asthmaNA50 yearsNAChildhood wheezy bronchitis, Childhood asthma9110 years41.75%Smoking history, Age, Low FEF2~~5₋7~~5%5823.3yearsNAHigh RV/ TLCAbbreviations: P, Prospective cohort; R, Retrospective cohort; US, United States; UK, United Kingdom; NA, not available; sSAD, small airways dysfunction; NOCB, non-obstructive chronic bronchitis; PRISm, preserved ratio impaired spirometry; EBTd, Exhaled Breath Temperature difference; FEV1/FVC, forced expiratory volume in 1 second to forced vital capacity ratio; BMI, Body Mass Index; DLCO, diffusing capacity of the lung for carbon monoxide; FVC/TLC, forced vital capacity to total lung capacity ratio; RV/ TLC, residual volume to total lung capacity ratio; VO, Variable airflow obstruction; FEF2~~5₋7~~5%, forced expiratory flow at 25–75% of the pulmonary volume.
In the 13 studies available for the meta-analysis,3,25,28–33,36–38,40,43 the incidence of progression from pre-COPD to COPD ranged from 5.0% to 61%. The included studies observed considerable heterogeneity (I^2^ = 97.7%, p < 0.001). Therefore, using the random effects model, the results demonstrated that the pooled incidence of progression from pre-COPD to COPD was 20% (95% CI 15–26%) (Figure 2). Figure 2Forest plot of the incidence pre-COPD progressing to COPD3,25,28–33,36–38,40,43 (n = 13, random effect).
Subgroup analysis was used to investigate heterogeneity in the study. Subgroup analyses were performed according to country, follow-up duration, year of publication, study design, and sample size of pre-COPD subjects (Table 2). Subgroup analyses suggested that follow-up duration (p = 0.006), study design (p = 0.003), and sample size of the pre-COPD cohort (p = 0.004) may influence the reported estimates of progression incidence from pre-COPD to COPD across studies. The subgroup meta-analysis showed the pooled incidence proportions were 27% (95% CI 18–35%) in studies with a follow-up duration ≥5 years, and 13% (95% CI 7–18%) in those with a follow-up duration <5 years. In the study design subgroup, the pooled incidence was 20% (95% CI 14–26%) with prospective cohort studies and 10% (95% CI 7–14%) with retrospective cohort studies. The subgroup analysis of pre-COPD sample size revealed that the pooled incidence of progression to COPD was the highest in studies with ≤ 100 subjects (33%, 95% CI 26–41%), higher than that in studies with 100–500 subjects (22%, 95% CI 10–33%), and the lowest in studies with ≥ 500 subjects (16%, 95% CI 9–23%). Table 2Subgroup Analysis of the Incidence of Progression From Pre-COPD to COPD3,25,28–33,36–38,40,43 (n=13)ParameterNumber of Included StudiesEffect Size95% CIPvalue****CountriesEastern^a^50.15(0.09 to 0.22)0.123Western^b^80.23(0.16 to 0.30)Follow-Up Time< 5years60.13(0.07 to 0.18)0.006≥5years70.27(0.18 to 0.35)Publication YearPre-202270.18(0.12 to 0.24)0.365Post-202260.23(0.14 to 0.33)Study DesignProspective110.20(0.14 to 0.26)0.003Retrospective20.10(0.07 to 0.14)Sample size of Pre-COPD≤10020.33(0.26 to 0.41)0.004100-50060.22(0.10 to 0.33)≥50050.16(0.09 to 0.23)Notes: ^a^China, Korea, Japan. ^b^United States, United Kingdom, Australia, Denmark.Abbreviations: CI, confidence interval.
Sensitivity analysis was performed by eliminating individual studies one at a time. The pooled incidence of progression from pre-COPD to COPD fluctuated between 17% and 22%, with little difference between the obtained results and the overall incidence, implying that our findings were stable The details of the sensitivity analysis are presented in Additional Table 2.
We used the funnel chart and Egger’s test to test the publication bias of the pooled incidence of progression from pre-COPD to COPD. Upon visual inspection, the funnel plot revealed significant asymmetry (Additional Figure 1). Egger’s test (P = 0.013) indicated the presence of publication bias.
We categorized these factors into three subcategories, namely demographic and behavioral characteristics, clinical symptoms and medical history, and physiological and imaging indicators, as per previous research (Table 3).44 We pooled ORs and HRs from multivariate analyses to assess the risk factors associated with the clinical progression of pre‑COPD. Among the investigated variables, five factors were found to be statistically significant predictors of age, smoking history, NOCB, PRISm, and asthma. Based on this, we combined ORs to obtain the summary ORs and their 95% CIs for the clinical progression factors of pre-COPD (Table 4). Similarly, we did the same analysis for HRs (Table 5). Due to the limited number of studies, funnel plots could not be estimated. Furthermore, we conducted descriptive analyses for risk factors that could not be quantitatively synthesized due to substantial differences in measurement methods, effect size units, definitions, or reporting formats. The remaining risk factors are detailed in Table 3.
Table 3Potential Risk Factors for Progression from Pre-COPD to COPDItemsRisk FactorsUnmodifiable FactorsModifiable FactorsPhysiological and imaging indicatorsPRISm^a,b^; Low FEF25-75%; sSAD; Low FEV3/FEV6; High RV/ TLC; Low DLCO; Early airflow limitation; variable airflow obstruction; Early below average FEV1 with accelerated decline; Persistently low FEV1, Below average FEV1; EBTd; FEV1/FVC<0.75; Low FVC/TLCct variable airflow obstructionClinical symptoms and medical historyChildhood asthma; Childhood wheezy bronchitis; Childhood pneumonia with comorbid asthma; Childhood pneumoniaWheezing; Dyspnea; Asthma^a,b^; NOCB ^a,b^Demographic and behavioral characteristicsAge^a,b^; Male sexSmoking history^a,b^; BMINotes: ^a^ Factors involved in the meta-analysis. ^b^ Factors showed statistical significance in the meta-analysis.
Table 4Meta-Analysis Results of OR-Based Progression of Pre-COPD to Major Risk Factors for COPDRisk FactorsNOR (95% CI)Effect ModelHeterogeneityI^2^P valueSmoking history33,27,404.08 (2.14,7.18)Random66.6%0.05Age229,361.09 (1.03,1.15)Random50.1%0.157PRISm325,30,402.92 (1.79,4.74)Random54.7%0.110NOCB225,272.07 (1.32,3.24)Fixed0.0%0.513Asthma225,362.50 (1.93,3.24)Fixed37.2%0.207Note: Age: Modelled as a continuous variable; pooled OR per 1-year increase. Smoking Smoking history was treated as a categorical variable, comparing current or former smokers with at least a minimal cumulative exposure (typically ≥1-10 pack-years, depending on the study) with never smokers or those with only negligible exposure.
Table 5Results of Meta-Analysis of HR-Based Progression of Pre-COPD to Major Risk Factors for COPDRisk FactorsNHR (95% CI)Effect ModelHeterogeneityI^2^P valueSmoking history234,432.21 (1.59,3.07)Fixed0.0%0.963NOCB224,342.46 (1.61,3.75)Fixed0.0%0.548Note: Smoking Highest cumulative smoking exposure categories vs lowest exposure or never smokers.
Demographic and behavioural attributes encompassed age, body mass index (BMI), and smoking history. Three studies assessed the correlation between age and the progression of pre-COPD to COPD. In the two studies included in the meta-analysis, age was analysed as a continuous variable. The pooled analysis showed that each 1-year increase in age was associated with a higher risk of progression from pre-COPD to COPD (ORs = 1.09, 95% CI 1.03–1.15, I^2^ = 50.1%, P = 0.157).29,36 Furthermore, one study modelled BMI as a continuous variable and found that lower BMI was associated with an increased risk of clinical progression from pre-COPD (per 1 kg/m^2^ OR = 0.88, 95% CI 0.79–0.98, P = 0.015).40 In contrast, another study dichotomised BMI at 25 kg/m^2^ and reported that participants with BMI≤25 kg/m^2^ had a markedly increased progression risk (OR = 2.40, 95% CI 1.43–4.03, P = 0.0009).27 Given the different BMI definitions in the two studies, we did not calculate a pooled odds ratio. In the meta-analysis, three cohort studies reported odds ratios for different levels of smoking exposure. In these studies, smoking history was defined as current or former smoking with at least a minimal cumulative exposure in pack-years. It was compared with never smoking or only negligible exposure. The pooled analysis indicated that individuals with a smoking history had a significantly increased risk of progression from pre-COPD to COPD (ORs = 4.08, 95% CI 2.14–7.18, I^2^ = 66.6%, P = 0.05).3,27,40 Based on two cohort studies reporting hazard ratios, the meta-analysis further showed that, compared with never smokers or those with very low cumulative smoking exposure, long-term smokers in the highest cumulative pack-year categories had approximately a twofold higher risk of developing COPD (HRs = 2.21, 95% CI 1.59–3.07, I^2^ = 0%, P = 0.963).34,43 Due to the limited number of studies, funnel plots could not be constructed.
Physiological and imaging indices included PRISm, reversible airflow obstruction (VO), RV/TLC ratio, small airway function indices (Low FEV3/FEV6, sSAD, low FEF25-75%), early airflow limitation, and FEV1/FVC < 0.75. A meta-analysis of three studies indicated that PRISm correlates with a heightened risk of COPD (HRs = 2.92, 95% CI 1.79–4.74, I^2^ = 54.7%, P = 0.110).25,30,40 Heterogeneity across the studies was moderate. Due to the limited number of studies, funnel plots could not be estimated. Two studies showed an association between reversible airflow obstruction and future risk of COPD (HR = 6.2, 95% CI 4.6–8.3, P < 0.001, OR = 3.87, 95% CI 2.46–6.39, P < 0.001).37,38 Due to the difference in the estimate effect unit, the pooled effect could not be evaluated. In addition, two investigations assessed the correlation between the RV/TLC ratio and COPD. The findings indicated that patients exhibiting a high RV/TLC ratio possessed a markedly elevated risk of getting COPD (OR = 5.689, 95% CI 2.446–13.228, P<0.001, OR = 1.30, 95% CI 1.03–1.65, P = 0.027).33,41 Nonetheless, data could not be pooled due to discrepancies in measurement techniques, such as computed tomography (CT) versus volumetric plethysmography. Three cohort studies reported that Low FEV3/FEV6 (HR = 2.11, 95% CI 1.48–3.03, P < 0.001),35 small‑airway dysfunction (sSAD) (HR = 2.74, 95% CI 2.07–3.61, P < 0.0001),24 and reduced FEF2~~5–7~~5% (HR = 3.31, 95% CI 1.65–6.63, P < 0.001) were each associated with future risk of COPD occurrence.43 Due to differences in indicator definitions and measurement methods, quantitative meta-analysis was not possible. However, all results uniformly underscore that small‑airway impairment substantially elevates the risk of COPD occurrence. Notably, a large-scale cohort study conducted in the United States identified a baseline FEV1/FVC ratio of <0.75 as the strongest predictor of future airflow limitation (OR = 15.32, 95% CI 9.14–25.69, P<0.0001).27 Similarly, a study from Denmark demonstrated a significant association between early airflow limitation and an increased risk of developing COPD (OR = 21.8, 95% CI 14.8–32.0, P < 0.0001).25 Data could not be aggregated due to substantive differences in definitional criteria, measurement methods.
Clinical symptoms and past medical history include NOCB, asthma, and respiratory symptoms (wheezing, dyspnea). Among the four studies analysed, two reported odds ratios (OR),25,27 and the other two supplied risk ratios (HR) were employed to assess the association between non‑obstructive chronic bronchitis and the probability of developing COPD.24,34 The meta-analysis demonstrated that non‑obstructive chronic bronchitis significantly increases the likelihood of developing COPD (ORs = 2.07, 95% CI 1.32–3.24, I^2^ = 0.0%, P = 0.513, HRs = 2.46, 95% CI 1.61–3.75, I^2^ = 0.0%, P = 0.548). In two studies, asthma was associated with the future occurrence of COPD (ORs = 2.50, 95% CI 1.93–3.24, I^2^ = 37.2%, P = 0.207).25,36 Heterogeneity across the studies was low. In addition, two studies separately reported associations of wheezing29 and dyspnea26 with increased future COPD risk, yielding ORs of 4.56 (95% CI 1.08–19.35, P = 0.04) and 1.69 (95% CI 1.14–2.51), respectively. Quantitative synthesis was not performed due to heterogeneity in symptom types and assessment instruments. Nonetheless, both suggest that respiratory symptoms may be an essential clinical signal for the progression of pre-COPD. More prospective studies are still needed to verify this in the future.
Our study presents a meta-analysis examining the incidence of progression from pre-COPD to COPD and its associated risk factors. The analysis revealed a pooled incidence of 20% for progression from pre-COPD to COPD. We discovered five statistically significant indicators linked to clinical development in pre-COPD: age, smoking history, NOCB, PRISm, and asthma. Understanding prognostic factors for pre-COPD clinical progression, including readily accessible objective indicators, is essential for formulating personalized therapeutic strategies for this chronic progressive disease. It can furnish patients and their families with critical information to facilitate informed decision-making.
This study summarizes all available data from population‑based analyses. It is worth noting that pre‑COPD, as a clinical state that still lacks a precise definition, exhibits diverse clinical phenotypes.7 Moreover, the included studies varied in design, sample origin, and geographical distribution, resulting in inevitable heterogeneity in results. The meta-analysis revealed that the aggregated incidence of progression from pre-COPD to COPD was 20%. Studies with more than five years of follow‑up reported a significantly higher incidence in the subgroup analysis by follow-up duration. This may indicate the temporal aspect of clinical progression in pre-COPD, underscoring the need for healthcare professionals to prioritize long-term surveillance of high-risk individuals. The Subgroup analysis stratified by study design demonstrated that the incidence rate was higher in prospective cohort studies (20%) than in retrospective studies (10%). This observation likely reflects standardized data‐collection methods in prospective studies, which are more effective in thoroughly documenting disease progression. The outcomes of retrospective studies were mainly derived from medical records and related databases. They were subject to the common limitations of their retrospective design, including selection bias, misclassification bias, and residual confounding.45 Subgroup analyses indicate that the incidence of progression from pre-COPD to COPD was elevated in studies with pre-COPD sample sizes of ≤ 100. This may be attributed to the propensity of small-sample studies to recruit high-risk populations or to exhibit selective bias, potentially resulting in an overestimation of incidence.
The funnel-plot asymmetry and Egger’s test indicate potential publication bias, which may arise from substantial heterogeneity in pre-COPD study criteria, hindering the publication of negative findings with low incidence rates. Additionally, there may be a preferential publication of novel data on clinical progression among individuals at high risk for COPD.
Currently, the precise pathological mechanisms underlying the progression from pre-COPD to COPD remain unclear. However, certain factors, such as advanced age and smoking, have been reported to be involved in the pathogenesis of COPD. Research has demonstrated that FEV1 and FVC decrease with age in healthy adults; however, the decrease in FEV1 is more significant.46 This may be attributed to the fact that lung function diminishes as we age, which results from changes in the shape of the thorax, decreased strength of the respiratory muscles and diaphragm, and reduced lung elasticity and retraction.47 The COPDGene study demonstrated that current smokers experienced a markedly worse decrease in lung function over a 10-year follow-up compared to persons who had previously smoked but had ceased.48 The biological effect of cigarette smoking on the development of COPD remains unclear. However, cigarette smoke components, such as nicotine, hydrocarbons, and carbon monoxide, are known to trigger chronic airway inflammation, oxidative stress, and a protease-antiprotease imbalance via multiple pathways, leading to alveolar destruction, airway remodeling, and a progressive decline in lung function.49,50
In this systematic review and meta-analysis, we evaluated PRISm, high RV/TLC ratio, reversible airflow obstruction (VO), indicators of small airway function (low FEV3/FEV6, sSAD, low FEF25-75%), early airflow limitation, FEV1/FVC < 0.75. Our meta-analysis revealed that PRISm is a significant risk factor for the progression to COPD. PRISm is a spirometric phenotype characterized by abnormal non-obstructive pulmonary function, exhibiting a normal forced expiratory volume in one second to forced vital capacity ratio (FEV1/FVC ≥0.7) but presenting a reduced forced expiratory volume in one second (FEV1%pred) or forced vital capacity (FVC%pred) of less than 80%.51 Despite not fulfilling the diagnostic criteria for COPD, prior research indicates that 22.2% of patients with PRISm progressed to GOLD grade 0 and 25% to GOLD grades 1 to 4 at a 5-year follow-up,52 exhibiting an elevated risk of all-cause mortality and respiratory diseases compared to individuals with normal lung function.52–57 Furthermore, Helena Backman et al58 discovered that PRISm patients who had never smoked had a comparable 10-year risk of progression to COPD (OR=3.66) to that of current smokers (OR=4.07) and former smokers (OR=1.52). Therefore, PRISm should be emphasized as an early screening indicator to actively monitor disease progression. Recent research indicates that the advancement of PRISm to COPD can be mitigated and mortality can be diminished by enhancing cardiovascular health indicators (eg, Life’s Essential Eight score) and managing smoking and obesity.59 The RV/TLC ratio can be measured using various methods, as is widely recognised. However, the absence of a uniform measurement method renders it impossible to derive quantitative summary results for RV/TLC. In our study, quantitative synthesis was precluded by heterogeneous effect-size metrics employed to assess reversible airflow obstruction (VO) across the included investigations. However, two high-quality cohort studies confirmed that VO was significantly associated with an increased risk of incident COPD (HR = 6.20, 95% CI 4.60–8.30, P < 0.001; OR = 3.87, 95% CI 2.46–6.39).37,38 Small airway dysfunction may be present in the pre-COPD stage. Due to the absence of overt symptoms initially, this illness is frequently neglected. Extensive cohort studies, including COPDGene and SPIROMICS, have demonstrated that small airway dysfunction, exemplified by diminished FEF25%–75% projected values, is significantly correlated with the severity of COPD and the deterioration of lung function.60,61 In this meta-analysis, quantitative summary results could not be obtained due to the different small airway function assessment metrics used in the included studies. The current GOLD recommendations define airflow obstruction in COPD using a fixed FEV1/FVC ratio of <0.7. However, this threshold may inaccurately assess the risk of early or moderate obstruction in both younger and older demographics.62,63 The differing FEV1/FVC criteria utilized in the two studies included in the meta-analysis (eg, early airflow limitation versus FEV1/FVC < 0.75) precluded the quantitative aggregation of their risk estimations.
Prior meta-analyses indicate that individuals with non-obstructive chronic bronchitis exhibit an elevated risk of progressing to chronic obstructive pulmonary disease (COPD), all-cause mortality, and respiratory illnesses.64 In agreement with previously published studies, the meta-analysis in the present study further confirmed that the disease was significantly associated with the risk of developing COPD in the future. Furthermore, there is a correlation between asthma and COPD.65,66 Our findings confirm that asthma is associated with the risk of developing COPD in the future. Enhancing management for this high-risk cohort may diminish the likelihood of future COPD and elevate quality of life. Nevertheless, additional studies are necessary to validate the efficacy of this COPD prevention strategy. For instance, the prevention of asthma should commence in childhood or even earlier,67 and proactive intervention strategies, such as the promotion of immunisation, maternal smoking cessation, and adolescent smoking prevention, can effectively reduce the risk of COPD in the future. Chronic cough and sputum symptoms are alleviated by treatments that target mucus hypersecretion in chronic bronchitis, such as expectorants and mucolytics. A previous meta-analysis demonstrated that patients in the chronic bronchitis (CB)/pre-COPD group treated with N-acetylcysteine (NAC) experienced a reduction in symptom burden and improved quality of life during the study period.68 Studies on whether respiratory symptoms directly increase the risk of developing COPD are still limited, and there is inconsistency in the findings.69–72 In this meta-analysis, quantitative synthesis was not feasible due to substantial heterogeneity in the nature, pathological basis, and clinical implications of the respiratory symptoms evaluated across the included studies.
This systematic review and meta-analysis had several limitations. First, there is significant heterogeneity in the incidence of pre-COPD progression to COPD. We performed subgroup analyses to explore potential explanations; however, other unidentified factors may have also contributed to the results. Second, there is yet no unequivocal definition of pre-COPD. Our research utilised the 2022 Global Initiative for Chronic Obstructive Lung Disease (GOLD) diagnostic standards. Third, most studies were designed as cohort studies, which may lead to bias. Furthermore, most of the included studies were from Western countries, which may restrict the generalizability of the study conclusions to Eastern countries or other locations. The search criteria might have potentially excluded eligible studies not in English due to the search being limited to the English language. Ultimately, sensitivity analysis was limited due to the small number of studies in this meta-analysis. Therefore, a prospective cohort study with high quality involving multiple institutions in different countries is imperative to draw a definitive conclusion.
In summary, this meta-analysis indicates an estimated 20% progression rate from pre-COPD to COPD. Key factors associated with increased risk include older age, smoking history, non-obstructive chronic bronchitis, PRISm, and co-existing asthma. These findings highlight identifiable risk profiles that could aid in stratifying patients within the pre-COPD population. Clinically, this supports enhanced monitoring and targeted early intervention in high-risk subgroups, such as optimising smoking cessation, managing chronic respiratory symptoms, and treating concurrent asthma. From a public health perspective, the results reinforce the value of early detection and multidimensional prevention strategies in at-risk populations. While the conclusions are tempered by the limited number of high-quality studies, significant heterogeneity, and the observational nature of included data, this synthesis provides a preliminary evidence base to guide clinical vigilance and future research. Prospective studies are needed to validate these risk factors and to assess whether early intervention can attenuate progression to established COPD.