Authors: Quanhao Yu, Feng Gao, Chuting Li, Jie Xia, Yanyuan Cao, Xiang Wang, Chuman Xiao, Jingjie Lu, Qian Liu, Jie Fan, Xiongzhao Zhu
Categories: Original Article, Goal-directed behavior, Habitual behavior, Obsessive-compulsive disorder, Reinforcement learning modeling
Source: International Journal of Clinical and Health Psychology : IJCHP
Previous research has found that compulsions in obsessive-compulsive disorder (OCD) are associated with an imbalance between goal-directed and habitual responses. However, the cognitive mechanisms underlying how goal-directed and habitual behaviors are learned, and how these learning deficits affect the response process, remain unclear. The present study aimed to investigate these cognitive mechanisms and examine how they were involved in the mechanism of compulsions.
A total of 49 patients with OCD and 38 healthy controls (HCs) were recruited to perform the revised “slip of action test”. A reinforcement learning model was constructed, and model parameters including learning rates, reinforcement sensitivity, and perseveration were estimated using a hierarchical Bayesian approach. Comparisons of these parameters were made between the OCD group and HCs, and the associations with performance during the outcome devalued stage and clinical presentations were assessed.
In the outcome devalued stage, patients with OCD exhibited greatet responsiveness to the devalued outcome, indicating their impairment in flexible and goal-directed behavioral control. Computational modeling further revealed that, during the instrumental learning stage, patients with OCD showed reduced learning rates, decreased perseveration, and heightened reinforcement sensitivity as compared with HCs. The learning rate and perseveration during instrumental learning were significantly correlated with the performance in the outcome devalued stage and compulsive scores in OCD.
The results indicate that patients with OCD exhibit deficits in updating the associative strength based on prediction errors and are more likely to doubt established correct associations during goal-directed and habitual learning. These deficits may contribute to the inflexible goal-directed behavioral control and are involved in the mechanism of compulsion in OCD.
Keywords: Obsessive-compulsive disorder, Goal-directed behavior, Habitual behavior, Reinforcement learning modeling
Obsessive-compulsive disorder (OCD) is a common and chronic psychiatric disorder affecting 2%-3% of the population (Stein et al., 2019). Compulsion, manifested as repetitive, ritualistic behaviors or mental acts, stands as one of the core symptoms of OCD and significantly impair the social functioning of individuals with OCD (Amerio, Tonna, Odone, Stubbs, & Ghaemi, 2016; Robbins, Vaghi, & Banca, 2019). To date, the neuropsychological mechanism of compulsion remains unclear, posing a substantial obstacle to the prevention and treatment of OCD.
Recent studies suggest that compulsions in OCD may be related to the imbalanced execution between the goal-directed and habitual actions (Gillan, Robbins, Sahakian, van den Heuvel, & van Wingen, 2016). Goal-directed behaviors are actions that are executed to achieve or avoid specific outcomes. These behaviors are highly adaptive but require more cognitive resources in a novel environments (Worbe, Savulich, de Wit, Fernandez-Egea, & Robbins, 2015). With repetition, such as daily routines, goal-directed actions can become habitual. Habitual behaviors are controlled by external stimulus-response associations and can be triggered automatically by certain stimulus (de Wit, Corlett, Aitken, Dickinson, & Fletcher, 2009). Habitual behaviors help individuals simplify the complex world, but can also lead to “slips of action” toward outcomes that are currently devalued (Gillan, 2021; Poldrack et al., 2005). The alility to flexibly shift between goal-directed and habitual responding is crucial for normal functioning in everyday life. Yet, this flexibility is compromised in patients with OCD and it is thought to be involved in the mechanism of compulsions.
The initial exploration of the imbalanced execution between goal-directed and habitual behavior in OCD was conducted using the outcome devaluation paradigm. This revealed that, compared to healthy controls (HCs), patients with OCD couldn't refrain from responding to the devalued stimuli (Gillan et al., 2011). Impairments in goal-directed behavior and an over-reliance on habitual behavior in OCD have also be observed in other studies using the contingency degradation paradigm and the two-step task and in the context of avoidance (Gillan et al., 2014).
While previous studies have indeed illuminated the impaired execution between goal-directed and excessive habitual behavioral control in patients with OCD, these investigations have primarily focused on behavioral responses during the outcome devaluation stage, neglecting the crucial process of instrumental learning of goal-directed and habitual behavior. Goal-directed and habitual learning are highly related and interdependent processes (de Wit & Dickinson, 2009; Dickinson, 1985; Valentin, Dickinson, & O'Doherty, 2007). During the initial stages of an individual's adaptation to a novel environment, goal-directed learning may predominates as individuals establish various stimulus-response-outcome associations and strive to optimize their actions(de Wit & Dickinson, 2009). As these associations become consistently reinforced through learning, the individual's behavioral system gradually shifts towards habitual behavior until a new outcome is required. However, the nature of learning processing in OCD, its effects on subsequently goal-directed and habitual responding process, and its association with compulsions remains unclear. This gap in understanding hinders our comprehension of OCD pathology.
The present study aimed to investigate the cognitive mechanisms underlying instrumental learning of goal-directed and habitual behaviors in patients with OCD and to examine how these mechanisms are involved in behavior execution associated with compulsion. To achieve this, we adopted a revised version of the “slip of action test”, which includes both the instrumental learning stage and the slip of action stage (Watson, van Wingen, & de Wit, 2018). A reinforcement learning model was applied to analyze the learning processes in both patients with OCD and healthy controls. The hypotheses were that 1) patients with OCD would exhibit deficits in the process of goal-directed and habitual learning, as reflected by the parameters of the reinforcement learning model; 2) the performance in the instrument learning phase would be strongly associated with behavior in devaluation phase in OCD, and would be specifically linked to the compulsion rather than obsession.
A total of 49 patients with OCD and 38 HCs participated in the present study. Patients with OCD were recruited from the psychology clinic at the Second Xiangya Hospital of Central South University, Changsha, Hunan, China. Inclusion criteria for OCD patients include a DSM-5 diagnosis of OCD, confirmed by two experienced psychiatrists, an age range of 16 and 45 years, and right-handedness. Exclusion criteria included primary diagnoses of other DSM-5 disorders such as schizophrenia, bipolar disorder, or anxiety disorders, as well as a documented history of any significant medical or neurological conditions. Of the 49 OCD patients, 20 were unmedicated. Among the 29 medicated patients, 28 were taking selective serotonin reuptake inhibitors (SSRIs), including sertraline, escitalopram oxalate, paroxetine, fluvoxamine, and fluoxetine. One patient was taking flupentixol-melitracen tablets. The HCs were recruited from local communities and universities. Inclusion criteria for HCs included no history of meeting the diagnostic criteria for any psychiatric or mood disorder under DSM-5, an age range of 16 and 45 years, and right-handedness. All participants provided written informed consent before completing the measures. The study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University.
The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used to assess the severity of obsessive and compulsive (OC) symptoms in patients (Goodman et al., 1989). All participants completed the Obsessive-compulsive Inventory-Revised (OCI-R), the Beck Depression Inventory (BDI), and the State-Trait Anxiety Inventory (STAI) to evaluate the OC symptoms, depression, and anxiety level. Verbal intelligence (IQ) was measured by the Chinese version of the Wechsler Intelligence Test III (Foa et al., 2002; Spielberger, Gonzalez-Reigosa, Martinez-Urrutia, Natalicio, & Natalicio, 1971).
We used a revised version of the “slip of action test” (Harold & Sellers, 2018), programmed in E-prime 2.0, to evaluate performance in the learning process and dual-system execution (see Fig. 1). This test comprised two the instrumental learning stage (Fig. 1a) and the outcome devalued stage (Fig. 1b). During the instrumental learning stage, participants were instructed to establish stimulus-response-outcome associations through trials and errors based on feedback. Each trial began with a black fixation “+” presented at the center of a white screen for a random duration of 2–4 seconds. Subsequently, a closed box labeled with a fruit (stimulus fruit) appeared in the center of the screen, and participants were instructed to respond by pressing either the right key or left key within a 2-second response window. One of the keys would trigger the appearance of another fruit (outcome fruit) inside the box and award a point. Faster and correct responses would result in more points (ranging from 1 to 5), while an incorrect key press would lead to an empty box with no points awarded. If no response was recorded within the time limit, “Too late” appeared on screen. Feedback was displayed for 1 second. Participants were instructed that their goal was to earn as many points as possible and remember the associations between stimulus fruits, responses, and outcome fruits. The stage consisted of 12 blocks with 12 trials in each, for a total 144 trials. There were 12 fruit images, forming six stimulus-response-outcome associations in total.
Fig. 1 The process of “slip of action test”. a, During the instrumental training stage, participants saw fruits on the outside of the box first, and then had to learn whether press left or right key to collect the fruit inside the box to establish and reinforce the stimulus-action-outcome association. Faster and correct responses led to higher point gains. In this example, the cherry stimulus is paired with the apple outcome, and the pear stimulus paired with the grape. b, During the outcome devalued stage, at the beginning of each block of trials, two certain fruit outcomes were devalued (indicated by two red crosses), signifying that participants should no longer respond to those outcomes, as doing so would lead to subtraction of points. Participants were instructed to respond the stimulus when the associated fruit outcome was not devalued and withhold respond to the devalued fruit (e.g., the apple is devalued so no response should be made to the cherry).
The outcome devaluation stage allowed for a direct assessment of relative habitual and goal-directed behavior execution. At the beginning of each trial of a block, all 6 outcome fruits were displayed on the screen for 5 seconds, with two of them devalued (indicated by two red crosses). Participants were instructed to continue responding to the still-valuable outcomes and to stop responding to the devalued outcomes, as doing so would lead to the subtraction of points. The outcome devaluation stage began only after participants had correctly completed the recollections test, where they were asked to identify the devalued outcome fruits. Following this, a fixation cross was presented for a random duration of 2.5–4.5 seconds. The stimulus fruit would appear for 1.5 seconds, during which participants had to decide whether to respond with the correct key or refrain from responding. Feedback was provided at the end of each block. In the devalued phase, nine blocks included all possible combinations of right and left responses paired with outcomes that were devalued. Each block consisted of 24 trials, where the six stimulus fruits were shown four times in random order. Additionally, there were three blocks, which did not contain devalued outcome fruit, and participants were instructed to press the correct key to earn points like the instrumental learning stage. Each filler blocks consisted of 12 trials, with each of the six stimuli fruits was shown twice in random order.
Before the instrument learning stage, participants completed a short test phase with four associations consisting of eight pictures of different drinks to ensure that the participants fully understood the rules of the task. After completing the instrumental learning stage, participants also completed paper-and-pencil questionnaires of contingency knowledge to evaluate whether they remembered the associations.
Two-sample t-tests and Chi-square tests were used to evaluate the demographic and clinical differences between patients with OCD and HCs.
The standard outcome measures for the slip of action task were accuracy rate (ACC) and reaction time (RT) in the instrument learning stage, as well as response rates (%) on valued and devalued trials during the outcome devaluation stage. The devaluation sensitivity index (DSI), reflecting the percentages of responses on valuable outcomes minus devalued outcomes, was also calculated as an indication of the sensitivity of the outcome value in the devaluation stage. A higher DSI suggests a greater tendency toward goal-directed behavior responding. The number of consecutive incorrect responses for each stimulus was also calculated.
A repeated measures ANCOVA was utilized to examine group differences in accuracy and response time during the instrument learning stage. Two-sample t-tests were used to evaluate the differences between the two groups in response rates (%) on valued and devalued trials during the outcome devaluation stage. The Mann-Whitney U test was employed to compare the number of consecutive incorrect responses in each stimulus for the first time between patients with OCD and HCs. Partial correlations were conducted to evaluate the relationship between task performance and clinical measures. For the comparision and correlation analyses, the covariates of verbal IQ and medication status were controled. All analyses were conducted in SPSS version 22 and R version 4.0.2.
This study employs the classical Q-Learning algorithm to model the process of action selection during the trial-by-trial instrumental learning stage (Schaaf, Jepma, Visser, & Huizenga, 2019). During each trial, there are two possible responses for each stimulus (press right key or left key) and participants assigns an expected value to each Vt(R) and Vt(L). These values are initialized to 0.5, and Vtis updated on each trial as following
During each trial, the expected value of a specific response linked to a specific stimulus could also be viewed as the associative strength, which increases when a response is reinforced. Associative strength was updated trial by trial based on prediction errors, which represent the discrepancy between the expected outcome Vt and actual outcome Rt. Larger prediction errors lead to greater changes in associative strength. Additionally, the learning rate parameter α regulats the impact of prediction errors on updating the associative strength. Higher learning rates (close to 1) indicate greater sensitivity to prediction errors and fast adaptation of associative strength, whereas lower learning rates (near 0) lead to slower adaptation.
The instrument learning stage consists of six specific stimulus-response-outcome associations. Using only one learning rate parameter, α, to describe this task may overlook the learning differences between these distinct associations. To better capture these variations, this study optimizes the classical Q-learning model by establishes separate learning rates for each type of stimulus-response association. Thus, Six differentVtype,t+1were updated separately on each trial according to the following
We defined a perseveration parameter τ to represent the tendency to repeat the previous response of the same stimulus. For individuals, the probability of making either response should be equal upon the first appearance of each stimulus type. Each type of stimulus-response association is independent of the others. Therefore, the response and outcome for a particular stimulus type will only influence subsequent occurrences of the same stimulus-response association. For trial t with specific stimulus and response k, we defined Ctype,tk to be 1 if the subject chose response k on the previous the same stimulus trial, and 0 otherwise.
In sum, there were three parameters in this learning rate α, reinforcement sensitivity β and perseveration τ. The probability of a particular choice i for a specific type of stimulus on a given trial t followed a softmax rule, as described by the following equation.
The parameter β, referred to as reinforcement sensitivity or inverse temperature, reflects the degree of randomness or noise in the decision-making process (Gershman, 2016; Schaaf, Jepma, Visser, & Huizenga, 2019). Lower β values indicate greater randomness in choices and reduced sensitivity to expected reward values, while higher β values reflect a stronger tendency to choose stimuli with higher expected rewards. The parameter τ determined the degree of the tendency to perseverate the same choice to a certain type of stimulus.
The model was estimated using a hierarchical Bayesian framework implemented in RStan (version 2.21.2), which employs Hamiltonian Markov Chain Monte Carlo sampling. Priors for the means of the group-level hyperparameters were assigned separately. For learning rates (α), we provided a prior beta (1.1, 1.1) distribution with range [0, 1]. The prior for reinforcement sensitivity (β) was a prior gamma (4.82, 0.88) distribution (Gershman, 2016). For perseveration (τ), we used a prior normal (0, 1) distribution (Gershman, 2016). Each subject-specific parameter was drawn from the distribution of its group-level parameter (Lim et al., 2019). The standard deviation of α and τ was given a prior half-normal (0, 0.17) distribution, and the standard deviation of β was drawn from a prior half-normal (0, 2) distribution.
We used 4 independent Markov chain Monte Carlo (MCMC) chains, each with 2000 burn-in samples. The convergence of Markov chains is assessed using the potential scale reduction factor R^, with values less than 1.1 indicating sufficient convergence (Brooks & Gelman, 1998; Gelman, Carlin, Stern, & Rubin, 1995). To examine the differences in the three learning rate (α), reinforcement sensitivity (β) and perseveration (τ) between patients with OCD and HCs, we calculated the posterior distribution of the group difference. The 95% HDI of the group difference that did not overlap with zero indicated credible group differences (Kruschke, 2011). We also explored the correlations between the model parameters and the standard measures in the slip of action task as well as the clinical characteristics of OCD with verbal IQ and medication status controlled as covariates.
As shown in Table 1, the two groups did not differ in terms of age and gender distribution. Verbal intelligence of patients with OCD was lower than that of HCs. Moreover, as expected, patients with OCD exhibited a higher level of OC, depressive, and anxiety symptoms than HCs (all p < 0.05).
The standard results of the instrumental learning stage are presented in Figs. 2a-c. In both groups, ACC during the instrumental learning stage gradually increased across blocks and then leveled off (Fig. 2a), while RT gradually decreased across blocks and eventually stabilized as well (Fig. 2b).
Fig. 2 Results from analyses of standard outcome measures. a and b, Accuracy and reaction times in each block of instrumental learning. Both groups had learned the correct response to make (press left or right key) in the presence of each stimulus through trial and error. c, There were no significance differences in the number of continuous incorrect responses in each type of stimulus between patients with OCD and HCs. d, The results of outcome devalued stage. Patients with OCD showed significantly lower response rate to valuable outcomes, a significantly higher response rate to devalued outcomes. OCD, obsessive-compulsive disorder; HCs, healthy controls; **, p < 0.01; ***, p < 0.001.
The 12 blocks were divided into three equally the beginning, middle, and end. A two–way repeated measure ANCOVA was conducted to examine the differences in ACC and RT between OCD and HCs. For ACC, results revealed a significant main effect of phase (F
(2,81) = 0.185, p < 0.001). The main effect of group (F
(1,82) = 0.185, p > 0.05) and the interaction effect between group and phase (F
(2,81) = 1.188, p > 0.05) were not significant. For RT, the main effect of group, the main effect of phase, and the interaction effect between group and phase were all not significant (F
(1,82) = 0.185, p > 0.05; F
(2,81) = 2.475, p > 0.05; F
(2,81) = 0.113, p > 0.05). As shown in Fig. 2c, after the first response error for a specific type of stimulus, there were no significant differences in the number of consecutive incorrect responses for each stimulus type between patients with OCD and HCs.
The results of the outcome devaluation stage are depicted in Fig. 2d. Three HCs who did not complete the outcome devaluation stage were excluded from comparison. Compared to HCs, the OCD group demonstrated a significantly lower response rate to valuable outcomes (t = -2.82, p < 0.01), a significantly higher response rate to devalued outcomes (t = 3.85, p < 0.001), and consequently, a significant decrease in the DSI (t = -3.93, p < 0.001).
Gelman-Rubin testing demonstrated that the model achieved good convergence, as all R^ values were less than 1.1. The learning rates for each association in OCD and HCs was depicited in Fig S1 a, b (see Supplementary materials). Results from computational modeling parameters showed that patients with OCD had significantly higher learning rates for one type of association (95%HDI [0.0135, 0.0255]), and significantly lower learning rates for four types of associations (95%HDI [-0.0145, -0.0417]; [-0.0719, -0.1886]; [-0.0012, -0.0150]; [-0.0093, -0.0188]) compared to HCs (see Fig. 3a, 3b, 3c, 3e, 3f). The learning rate for one type of association did not differ between groups (Fig. 3d). Moreover, compared to HCs, patients with OCD exhibited higher reinforcement sensitivity (95% HDI [0.45, 1.01], Fig. 3g) and lower perseveration (95% HDI [-0.22, -0.25], Fig. 3h), particularly in the first half of the instrumental learning phase (95% HDI [-0.23, -0.26], Fig S1 c, d).
Fig. 3 Results from reinforcement learning model. a-f, group differences in the learning rate of 6 types of associations. g, OCD patients had higher reinforcement sensitivity as compared with HCs in the instrumental learning. h, OCD patients had reduced preservation as compared with HCs. OCD, obsessive-compulsive disorder; HCs, healthy controls; *, The difference between the two groups was significant.
For the partial correlation analyses, six patients with OCD who did not memorize the association's contingency and three healthy controls who did not complete the outcome devaluation stage were excluded. Results were presented in Fig. 4.
Fig. 4 The relationship between parameters in instrumental learning, performance in the outcome stage, and compulsive severity in patients with OCD, was analyzed with verbal IQ and medication status as covariates. a, the mean learning rate exhibited a positive correlation with the rate of response to valuable outcomes. b, the reinforcement sensitivity parameter exhibited a significant negative correlation with the rate of response to devalued outcomes. c, reinforcement sensitivity parameter exhibited a significant positive correlation with the index of devaluation sensitivity (DSI). d, the perseveration showed a significant negative correlation with the rate of response to devalued outcomes. e, perseveration showed significant negative correlations between Y-BOCS compulsive scores. f, mean of all type of learning rate showed significant negative correlations between Y-BOCS compulsive scores. OCD, obsessive-compulsive disorder; HCs, healthy controls.
Specifically, in patients with OCD, the learning rate was found to be significantly positively correlated with the rate of response to valuable outcomes (mean overall learning r = 0.372, p < 0.05, Fig. 4a; mean 4 lower learning r = 0.411, p < 0.05). Additionally, significant negative correlations were observed between reinforcement sensitivity and the rate of response to devalued outcomes (OCD: r = -0.354, p < 0.05, Fig. 4b; HCs: r = -0.401, p < 0.05), and significant positive correlations were found between reinforcement sensitivity and the DSI (OCD: r = 0.409, p < 0.01, Fig. 4c; HCs: r = 0.385, p < 0.05) in both groups. Perseveration was significantly negatively correlated with the rate of response to devalued outcomes in OCD patients (r = -0.348, p < 0.05, Fig. 4d). Correlation results for HCs were shown in Fig S2 (see Supplementry mateirlas).
The partial correlation analyses revealed that patients with OCD who had higher Y-BOCS compulsive scores showed lower learning rates (mean overall learning r = -0.372, p < 0.05; mean 4 lower learning r = -0.426, p < 0.05, Fig. 4e, Fig S3) and lower perseveration parameters (r = -0.376, p < 0.05, Fig. 4f). No other significant correlations were observed.
The present study utilized computational modeling to explore the cognitive mechanisms underlying goal-directed and habitual learning in patients with OCD, with a particular focus on how these mechanisms influence goal-directed and habitual responses and compulsive behaviors. The results showed that OCD patients exhibited stronger responses to devalued outcomes. The reinforcement learning model further revealed that OCD patients had a lower learning rate, higher reinforcement sensitivity, and reduced perseveration when learning new stimulus-response-outcome associations. These learning deficits were linked to impaired goal-directed and habitual behavior execution, which was associated with the severity of their compulsions. These findings support our hypothesis that OCD patients exhibit abnormalities in behavior learning processes, which strongly influence subsequent dual-system behavior execution. Notably, these abnormalities were specifically linked to compulsions rather than obsessions, providing further insight into the psychological mechanisms underlying compulsive behavior in OCD.
At the outcome devaluation stage, our study found that patients with OCD exhibited greater responses to devalued outcomes and had higher DSI compared with HCs. These findings are consistent with previous research and indicate that after goal-directed and habitual behavior learning, patients with OCD were less sensitive to the outcome value change, and showed over-reliance on habitual response in the behavior execution stage (Gillan et al., 2011). This response pattern aligns with the hallmark features of compulsions, which are characterized by insensitivity to outcomes, even when these outcomes become excessive or seemingly irrational (Gillan, 2021).
While much research has focused on the imbalanced dual-system behavior execution, few studies have explored the learning process in OCD, overlooking the relationship between dual-system behavior learning and subsequent execution. In the present study, we combined the standard indices and computational modeling parameters to reveal the specific instrumental learning process of OCD. Results from standard indices showed no significant differences in ACC and RT during the instrumental learning stage between the two groups. Additionally, patients with OCD did not exhibit impairment in promptly adjusting their behavior in response to negative feedback, as evidenced by the number of continuous incorrect responses in each stimulus. These findings suggested that both groups may have the capacity to learn the stimulus-response-outcome associations through trial and error. However, these explicit behavioral indices only demonstrate that both groups successfully learned these associations, without capturing how individuals learn during the instrumental learning phase.
Further insights from computational modeling revealed that OCD patients exhibited a lower learning rate, higher reinforcement sensitivity, and reduced perseveration during behavior learning. Among the six types of associations, OCD patients demonstrated a lower learning rate for four types, but a higher learning rate for one (Type 1 associations). The relatively higher learning rate for Type 1 may be attributed to physical similarities between stimuli, such as color or shape. For instance, Type 1, which pairs a red apple with a red cherry, is likely easier to learn due to these shared visual characteristics. OCD patients had a higher learning rate for this association, while showing lower learning rates for the others. This may indicate that, unlike HCs, whose learning rates display a more gradual, gradient-like pattern across multiple associations, suggesting a balanced approach to learning, OCD patients may exhibit a disproportionate focus on certain associations. This could reflect an overemphasis on specific connections, such as the easier ones, at the expense of learning others (details illustrated in Fig S1). Overall, despite association 1, OCD patients tended to have lower learning rate than HCs. The lower learning rates may suggest that OCD patients struggle with updating associative strength based on prediction errors when learning multiple associations. This finding aligns with previous studies, which have shown that patients with OCD exhibit reduced learning efficiency, potentially influenced by beta-gamma activity in the medial orbitofrontal cortex (Grover, Nguyen, Viswanathan, & Reinhart, 2021; Hiebert et al., 2020). Patients with OCD also presented a lower tendency to persist with the same responses within the same type of association. Considering that both groups achieved an ACC of over 90% at the end of the instrumental learning stage, it may be inferred that perseveration is approximately equivalent to the tendency to persist in correct responses within the same type of association. Also our results show that the difference in perseveration primarily be attributed to the performance at the beginning of the instrumental learning stage. Thus, lower perseveration are less likely to maintain "stickiness" to correct responses and are more sensitive to negative feedback, meaning they tend to doubt previously established associations. This reduced "stickiness" (i.e., increased switching between responses) when learning optimal behaviors has also been observed in other studies (Fradkin, Ludwig, Eldar, & Huppert, 2020; Kanen, Ersche, Fineberg, Robbins, & Cardinal, 2019; Ruan et al., 2023), collectively suggesting that OCD patients may place less weight on prior experiences and engage more in over-exploratory behaviors. Additionally, patients with OCD showed heightened sensitivity to negative feedback, aligning with the clinical characteristics of compulsions. OCD patients often exhibit excessive concern with avoiding negative consequences rather than seeking rewards, and their compulsions frequently involve repetitive behaviors that rigidly adhere to rules, initially aimed at alleviating or preventing unpleasant or undesirable outcomes (Chamberlain & Menzies, 2009; Voon et al., 2015). In sum, the analyses of standard outcome measures did not show group differences in the learning phase. The alterations in OCD patients were only apparent when exploring parameters derived from the computational modeling analysis. The findings from reinforcement learning modeling, which support our hypothesis 1, revealed the cognitive mechanisms in the goal-directed and habitual learning in OCD, and provide a more expressive understanding of instrumental learning deficits in OCD.
Further correlation analysis in the present study revealed that the learning features in OCD was significantly correlated with their subsequent performance in dual-system behavior execution. Patients with OCD exhibited a higher sensitivity to expected rewards in behavior learning process but respond more to devalued outcomes. This suggests that OCD patients may overly rely on expected value during behavior learning, leading to the formation of excessively strong stimulus-response associations. Such over formed habitual behaviors makes it challenging for them to adjust to new goals or adapt to changing environments. Also, in the present study, we found that the performance in the instrumental learning stage was significantly correlated with the severity of compulsions rather than the obsessions. These findings supported our hypothesis 2, clarifying the potential connection between the goal-directed learning and the subsequent impaired goal-directed and habitual responding in patients with OCD. They also strengthen our insight into the mechanism of compulsions (Gillan, Kosinski, Whelan, Phelps, & Daw, 2016; Peng et al., 2022; Zainal et al., 2023). During the past decades, cognitive-behavioral theory has been the dominant framework for explaining the underlying psychological mechanism of OCD. According to this theory, patients with OCD often engage in compulsive behaviors as a way to avoid potential negative consequences or discomfort and to neutralize anxiety or distress stemming from particular painful obsessions (Salkovskis, 1985). However, recent studies have proposed alternative hypotheses to clarify the relationship between obsessions and compulsions in OCD. Some studies have proposed that compulsive behaviors may not always arise as a direct consequence of obsessions, suggesting that such behaviors (e.g., ritualizing) can manifest independently (Robbins, Gillan, Smith, de Wit, & Ersche, 2012). This observation highlighted that the possibility that compulsions may function as an independent factor, further suggesting that compulsions are phenomenologically distinct from obsessions. The present study specifically characterizes the cognitive underpinnings of goal-directed and habitual learning and responding as being associated with compulsions in patients with OCD, providing some support for these emerging theories.
The current study has several limitations. First, the results of the slip of action test cannot definitively determine whether the bias toward habits is due to excessive reliance on habits, weak goal-directed control, or a combination of both. Further research could use different paradigms or neuroimaging methods to clarify this hypothesis. Second, more than half of the patients with OCD were on pharmacotherapy, mainly SSRIs, which may have reduced the observed differences between groups (Voon et al., 2020).
Patients with OCD exhibit deficiency in goal-directed and habitual learning, characterized by an inability to update the association strength in response to prediction errors, and are more likely to doubt the correct associations that have been established. These instrumental learning deficits influenced the subsequently impaired goal-directed and habitual control associated with compulsion in OCD. These findings provide important insight into the pathophysiology of OCD.
The authors affirm that all procedures contributing to this work adhere to the ethical standards set by the Institutional Ethics Board of the Second Hospital of Xiangya, Central South University.
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
This work was supported by the National Natural Science Foundation of China [grant number 82201673], and Hunan Provincial Innovation Foundation for Postgraduate [grant number CX20220356].
Jie Fan, Email: fanjie1025@csu.edu.cn.
Xiongzhao Zhu, Email: xiongzhaozhu@csu.edu.cn.